鑹炬粙鐥呮湁鏈涜娌绘剤!鍩哄洜缂栬緫鎴愬姛娓呴櫎灏忛紶浣撳唴HIV鐥呮瘨
鏃ユ湡:2019-07-08 15:07

(鍗曡瘝缈昏瘧:鍗曞嚮)

Researchers who eliminated HIV from mice say their results are an important advance in efforts to develop a cure for HIV infection in people.
鐮旂┒浜哄憳杩戞棩娓呴櫎浜嗗皬榧犱綋鍐呯殑鑹炬粙鐥呮瘨锛屽苟琛ㄧず杩欓」鐮旂┒缁撴灉鏄湪鐮旂┒娌绘剤浜虹被鑹炬粙鐥呮瘨鎰熸煋鏂归潰鍙栧緱鐨勯噸瑕佽繘灞曘€?br />This is the first time that the AIDS-causing virus has been eradicated from the genomes of living animals, according to the authors of the study.
鐮旂┒鎶ュ憡鐨勪綔鑰呯О锛岃繖鏄汉绫婚娆′粠娲讳綋鍔ㄧ墿鐨勫熀鍥犵粍涓畬鍏ㄦ秷闄よ壘婊嬬梾姣掋€?br />"Our study shows that treatment to suppress HIV replication and gene editing therapy, when given sequentially, can eliminate HIV from cells and organs of infected animals," said co-senior author Kamel Khalili, professor and chair of neuroscience at Temple University in Philadelphia.
鈥滄垜浠殑鐮旂┒琛ㄦ槑锛屽惊搴忚繘琛屾姂鍒惰壘婊嬬梾姣掑鍒剁殑娌荤枟鍜屽熀鍥犵紪杈戞不鐤楀彲浠ユ秷闄よ鎰熸煋鍔ㄧ墿浣撳唴缁嗚優鍜屽櫒瀹樹腑鐨勮壘婊嬬梾姣掆€濓紝璐瑰煄澶╂櫘澶у绁炵粡绉戝鏁欐巿鍏间富浠汇€佽鏂囪祫娣卞悎钁楄€呭崱杩堝嫆路鍗″埄鍒╄銆?br />The work was a collaboration with researchers at the University of Nebraska Medical Center.
杩欓」宸ヤ綔鏄笌鍐呭竷鎷夋柉鍔犲ぇ瀛﹀尰瀛︿腑蹇冪殑鐮旂┒浜哄憳鍚堜綔瀹屾垚鐨勩€?br />Current HIV treatment uses antiretroviral therapy (ART), which suppresses HIV replication but does not eliminate the virus from the body. ART is not a cure for HIV and requires lifelong use.
鐩墠鐨勮壘婊嬬梾姣掓不鐤椾娇鐢ㄦ姉閫嗚浆褰曠梾姣掔枟娉曪紝鍙互鎶戝埗鑹炬粙鐥呮瘨鐨勫鍒讹紝浣嗘棤娉曞皢鐥呮瘨浠庝綋鍐呮秷闄ゃ€傛姉閫嗚浆褰曠梾姣掔枟娉曚笉鑳芥不鎰堣壘婊嬬梾姣掞紝闇€瑕佺粓鐢熶娇鐢ㄣ€?/p>

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In this study, the researchers used a gene editing system called CRISPR-Cas9 to remove large fragments of HIV DNA from infected cells, along with a new drug regimen called long-acting slow-effective release (LASER) ART.
鍦ㄨ繖椤圭爺绌朵腑锛岀爺绌朵汉鍛樹娇鐢ㄤ簡涓€绉嶅悕涓篊RISPR-Cas9鐨勫熀鍥犵紪杈戠郴缁燂紝浠庡彈鎰熸煋鐨勭粏鑳炰腑鍘婚櫎杈冨ぇ鐨勮壘婊嬬梾姣掕劚姘ф牳绯栨牳閰哥墖娈碉紝鍚屾椂浣跨敤浜嗕竴绉嶅悕涓洪暱鏁堢紦閲婏紙婵€鍏夛級鐨勬柊鑽枟娉曘€?br />In this therapy, antiretroviral drugs are placed in nanocrystals that travel to tissues where HIV is likely to be lying dormant. The nanocrystals are stored within cells for weeks and slowly release the drugs.
鍦ㄦ不鐤楄繃绋嬩腑锛屾姉閫嗚浆褰曠梾姣掕嵂鐗╄鏀剧疆鍦ㄧ撼绫虫櫠浣撲腑锛屽苟琚繍閫佸埌鍙兘娼滀紡鐫€鑹炬粙鐥呮瘨鐨勭粍缁囥€傜撼绫虫櫠浣撹鍌ㄥ瓨鍦ㄧ粏鑳炲唴鏁板懆锛岀紦鎱㈤噴鏀捐嵂鐗┿€?br />Mice with HIV were first treated with LASER ART and then with gene editing. This approach eliminated HIV DNA from about one-third of the mice. However, research on animals may not produce the same results in humans.
鐮旂┒浜哄憳棣栧厛鐢ㄦ縺鍏夋姉閫嗚浆褰曠梾姣掔枟娉曟不鐤楁劅鏌撹壘婊嬬梾姣掔殑灏忛紶锛屼箣鍚庝娇鐢ㄥ熀鍥犵紪杈戞妧鏈€傝繖绉嶆不鐤楁柟娉曟秷闄や簡绾︿笁鍒嗕箣涓€灏忛紶浣撳唴鐨勮壘婊嬬梾姣掕劚姘ф牳绯栨牳閰弄€傜劧鑰岋紝瀵瑰姩鐗╃殑鐮旂┒鍙兘涓嶄細鍦ㄤ汉绫昏韩涓婅揪鍒扮浉鍚岀殑鏁堟灉銆?br />"The big message of this work is that it takes both CRISPR-Cas9 and virus suppression through a method such as LASER ART, administered together, to produce a cure for HIV infection," Khalili said in a university news release.
鍗″埄鍒╁湪涓€浠藉ぇ瀛︽柊闂荤涓:鈥滆繖涓€鐮旂┒鐨勯噸瑕佷俊鎭槸锛屽畠闇€瑕佷娇鐢–RISPR-Cas9鍩哄洜缂栬緫锛屽苟閫氳繃婵€鍏夋姉閫嗚浆褰曠梾姣掔枟娉曠瓑鏂规硶鎶戝埗鐥呮瘨锛屼袱绉嶆柟娉曚竴璧蜂娇鐢紝鎵嶈兘娌绘剤鑹炬粙鐥呮瘨鎰熸煋銆傗€?br />"We now have a clear path to move ahead to trials in nonhuman primates and possibly clinical trials in human patients within the year," added Khalili, who also directs Temple's neurovirology center and its neuroAIDS center.
鈥滅幇鍦ㄦ垜浠湁涓€鏉℃竻鏅扮殑閬撹矾锛屾垜浠彲浠ュ湪骞村唴瀵圭伒闀跨被鍔ㄧ墿杩涜璇曢獙锛屼篃鍙兘瀵硅壘婊嬬梾鎰熸煋鑰呰繘琛屼复搴婅瘯楠屸€濓紝鍚屾椂涓荤澶╂櫘澶у绁炵粡鐥呮瘨瀛︿腑蹇冨拰绁炵粡鑹炬粙鐥呬腑蹇冪殑鍗″埄鍒╄ˉ鍏呰銆?br />The results were published online July 2 in the journal Nature Communications.
璇ョ爺绌剁粨鏋滀簬7鏈?鏃ュ彂琛ㄥ湪銆婅嚜鐒堕€氳銆嬫潅蹇楃綉缁滅増涓娿€?br />

鍒嗕韩鍒?/div>
閲嶇偣鍗曡瘝
  • genen. 鍩哄洜
  • virusn. 鐥呮瘨锛岀梾鍘熶綋
  • lasern. 婵€鍏夛紝闀皠
  • eliminatev. 闄ゅ幓锛屽墧闄? 蹇界暐
  • infectionn. 浼犳煋锛屽奖鍝嶏紝浼犳煋鐥?/span>
  • collaborationn. 鍚堜綔锛岄€氭晫
  • approachn. 鎺ヨ繎; 閫斿緞锛屾柟娉?v. 闈犺繎锛屾帴杩戯紝鍔ㄦ墜澶勭悊
  • producen. 浜у搧锛屽啘浣滅墿 vt. 鐢熶骇锛屾彁鍑猴紝寮曡捣锛屽垎濞╋紝鍒剁墖
  • releasen. 閲婃斁锛岃娓★紝鍙戣 vt. 閲婃斁锛岃涓庯紝鍑嗕簣鍙戣〃锛屽彂
  • dormantadj. 鐫$湢鐘舵€佺殑锛岄潤姝㈢殑 [璁$畻鏈篯 闈欐鐨?